Phosphate Study – IMPHOS http://imphos.org/ Wed, 05 Jan 2022 21:59:44 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://imphos.org/wp-content/uploads/2021/08/IMPHOS-icon-150x150.jpg Phosphate Study – IMPHOS http://imphos.org/ 32 32 Dr. Monk on the emergence of NaPi2b as a target in ovarian cancer https://imphos.org/dr-monk-on-the-emergence-of-napi2b-as-a-target-in-ovarian-cancer/ Wed, 05 Jan 2022 21:59:44 +0000 https://imphos.org/dr-monk-on-the-emergence-of-napi2b-as-a-target-in-ovarian-cancer/ Bradley J. Monk, MD, FACS, discusses the emergence and utility of NaPi2b as a target in ovarian cancer. Bradley J. Monk, MD, FACS, FACOG, Professor, Division of Gynecologic Oncology, Arizona Oncology (US Oncology Network), University of Arizona College of Medicine, Creighton University School of Medicine at St. Joseph’s Hospital, Medical Director, Gynecologic Program , US […]]]>

Bradley J. Monk, MD, FACS, discusses the emergence and utility of NaPi2b as a target in ovarian cancer.

Bradley J. Monk, MD, FACS, FACOG, Professor, Division of Gynecologic Oncology, Arizona Oncology (US Oncology Network), University of Arizona College of Medicine, Creighton University School of Medicine at St. Joseph’s Hospital, Medical Director, Gynecologic Program , US Oncology Research Network, Co-Director, GOG Partners, discusses the emergence and utility of NaPi2b as a target in ovarian cancer.

NaPi2b, a sodium-dependent phosphate transporter, says Monk. NaPi2b is targeted by the investigational antibody-drug conjugate upifitamab rilsodotin (UpRi), which is a humanized monoclonal antibody with a specific linker and auristatin payload. The agent also has a high drug-to-antibody ratio, Monk explains. Additionally, DolaLock auristatin is controlled by a spectator effect that allows the payload to be selectively released into the tumor, Monk adds.

Overall, research has been done to optimize the dosage of UpRi so that patients can continue treatment for a long time, Monk continues. The FDA granted UpRi expedited designation in August 2020 for the treatment of patients with high-grade platinum-resistant serous ovarian cancer who have received up to 3 prior lines of systemic therapy or 4 prior lines of systemic therapy, regardless of their platinum status. In addition, the first UPLIFT phase 1/2 human study (NCT03319628) is currently recruiting patients with platinum-resistant ovarian cancer or metastatic non-small cell lung cancer to assess the safety and efficacy of UpRi in tumors likely to express NaPi2b, Monk concludes.


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Analysis of Malaysia Neurofeedback System Market Size 2021 by Major Key Players https://imphos.org/analysis-of-malaysia-neurofeedback-system-market-size-2021-by-major-key-players/ Tue, 04 Jan 2022 01:50:45 +0000 https://imphos.org/analysis-of-malaysia-neurofeedback-system-market-size-2021-by-major-key-players/ New Jersey, United States, – The global Malaysia Neurofeedback System market report comprises an in-depth analysis that covers core regional trends, market dynamics, and provides the market size at the national level of the market industry. Some major aspects considered during the research included, product description, product classification, industry structure, various players in the Malaysia […]]]>

New Jersey, United States, – The global Malaysia Neurofeedback System market report comprises an in-depth analysis that covers core regional trends, market dynamics, and provides the market size at the national level of the market industry. Some major aspects considered during the research included, product description, product classification, industry structure, various players in the Malaysia Neurofeedback System market, etc. The market report provides the values ​​for the historical period along with the forecast period and% CAGR measured for individual segments and regional markets.

The report focuses on the global companies operating in the Malaysia Neurofeedback System market providing data points such as company profiles, product picture and description, capacity, production, value, revenue and contact details. This research provides key statistics on the state of the industry and is an important source of direction and direction for companies and individuals involved in the market. In addition to CAGR forecast, various other parameters such as year-over-year market growth, qualitative and quantitative information are presented. Key points such as market size, value, volume, product portfolio, market explanation and classification are shown. Additionally, current trends, technological advancements in Malaysian Neurofeedback System market are explained.

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The Major Players Covered By Malaysia Neurofeedback Systems Markets:

  • BrainMaster Technologies
  • BEE Medic
  • Investigation
  • Mitsar
  • Thought technology
  • Media of the mind
  • Portable detection

Market segmentation of automated drug delivery systems:

The Automated Drug Delivery Systems market report has categorized the market into segments comprising by product type and application. Each segment is evaluated based on share and growth rate. Meanwhile, analysts looked at potential areas that could prove rewarding for builders in the years to come. The regional analysis includes reliable forecast on value and volume, thereby helping market players to acquire in-depth insights into the entire industry.

Malaysia Neurofeedback Systems Market Split By Type:

  • Slow cortical potential neurofeedback (SCP-NF)
  • Low Energy Neurofeedback System (LENS)
  • Hemoencephalographic Neurofeedback (HEG)
  • Other

Malaysia Neurofeedback Systems Market Split By Application:

  • ADHD Treatment
  • Other clinical use
  • Non-medical

Based on geography: North America (United States, Canada and Mexico), Europe (Germany, France, United Kingdom, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina and Colombia, etc.), Middle East and Africa (Saudi Arabia, United Arab Emirates, Egypt, Nigeria and South Africa).

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Scope of Malaysia Neurofeedback System Market Report

Report attribute Details
Market size available for years 2021 – 2028
Reference year considered 2021
Historical data 2015 – 2019
Forecast period 2021 – 2028
Quantitative units Revenue in millions of USD and CAGR from 2021 to 2027
Covered segments Types, applications, end users, etc.
Cover of the report Revenue forecast, company ranking, competitive landscape, growth factors and trends
Regional scope North America, Europe, Asia-Pacific, Latin America, Middle East and Africa
Scope of customization Free customization of reports (equivalent to 8 working days for analysts) with purchase. Add or change the scope of country, region and segment.
Price and purchase options Take advantage of custom shopping options to meet your exact research needs. Explore purchasing options

Key questions answered in the report:

  • What is the growth potential of the Malaysia Neurofeedback System markets?
  • Which product segment will take the lion’s share?
  • Which regional market will emerge as a precursor in the years to come?
  • Which application segment will grow at a sustained rate?
  • What are the growth opportunities that could emerge in the lock washer industry in the years to come?
  • What are the main challenges that the global Neurofeedback System markets in Malaysia may face in the future?
  • Who are the leading companies in the global Malaysian Neurofeedback System market?
  • What are the main trends that are positively impacting the growth of the market?
  • What are the growth strategies considered by the players to maintain their grip on the global Malaysia Neurofeedback System market?

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The study thoroughly explores the profiles of the major market players and their main financial aspects. This comprehensive business analyst report is useful for all existing and new entrants when designing their business strategies. This report covers the production, revenue, market share and growth rate of the Malaysia Neurofeedback System market for each key company, and covers the breakdown data (production, consumption, revenue and market share) by regions, type and applications. Historical breakdown data of Malaysia’s Neurofeedback System from 2016 to 2020 and forecast to 2021-2029.

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Solid Phosphate Fertilizer Market Overview with Detailed Analysis, Competitive Landscape, Forecast Till 2026 https://imphos.org/solid-phosphate-fertilizer-market-overview-with-detailed-analysis-competitive-landscape-forecast-till-2026/ Sat, 01 Jan 2022 13:12:22 +0000 https://imphos.org/solid-phosphate-fertilizer-market-overview-with-detailed-analysis-competitive-landscape-forecast-till-2026/ The Solid Phosphate Fertilizers Market research report offers a comprehensive analysis of this business space. The key trends that define the Solid Phosphate Fertilizers market during the analysis period are mentioned in the report alongside other factors such as regional scope and regulatory outlook. Further, the document details the impact of current industry trends on […]]]>

The Solid Phosphate Fertilizers Market research report offers a comprehensive analysis of this business space. The key trends that define the Solid Phosphate Fertilizers market during the analysis period are mentioned in the report alongside other factors such as regional scope and regulatory outlook. Further, the document details the impact of current industry trends on key market driving factors as well as key challenges.

The study also provides a summary of the competitive spectrum as well as an in-depth assessment of commodities and downstream buyers.

Elaboration of the competitive landscape of the solid phosphate fertilizers market:

  • According to the document, the competitive spectrum of the solid phosphate fertilizer market includes companies such as Eurochem, Phosagro, PotashCorp, OCP, ICL, Yara International ASA, Agrium, Coromandel International, CF Industries and The Mosaic.
  • The study provides crucial information regarding production patterns of manufactured items, income generated as well as company profile, among others.
  • The report also highlights the market share held by each company and their respective gross margins.

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Overview of the Regional Scope of the Solid Phosphate Fertilizers Market:

  • The research report divides the geographic landscape of the Solid Phosphate Fertilizer market into North America (United States, Canada, and Mexico), Europe (Germany, France, United Kingdom, Russia, and Italy), Asia-Pacific (China, Japan). , Korea, India and Southeast Asia), South America (Brazil, Argentina, etc.), Middle East and Africa (Saudi Arabia, Egypt, Nigeria and South Africa).
  • It provides a comprehensive analysis of the regional contribution in terms of the projected growth rate of each geography over the forecast period.
  • The profits generated by each region and its individual production volume as well as the market share of each province are cited in the document.
  • The report also provides data regarding pricing models, profit margins, value and consumption projections, which can further help stakeholders and investors to make timely decisions.

Other Information Mentioned In The Solid Phosphate Fertilizer Market Report:

  • Citing the product type, the report divides the market into diammonium phosphate (DAP), monoammonium phosphate (MAP), and superphosphate.
  • The document provides data relating to volume and revenue projections for each type of product.
  • Important information regarding the production models, growth rate and market share of each product fragment during the study period is given in the study.
  • In addition, a comparative assessment regarding the pricing model of the product is provided in the report.
  • According to the scope, the report categorizes the solid phosphate fertilizer market into fertilizer industry and crop cultivation.
  • The report works out the market share of each application segment and its respective growth estimates over the projected period.

Research on the solid phosphate fertilizer market answers the following questions:

  • Which end user is likely to influence the growth of the solid phosphate fertilizer market?
  • Which regional market has the highest market attractiveness in 2020?
  • How are consumption trends affecting the operations of market players in the Solid Phosphate Fertilizers Market?
  • Why are market players aiming to expand their presence in region 1?
  • What is the growth outlook of the Solid Phosphate Fertilizers market in different regions due to COVID-19?

Key Findings of the Solid Phosphate Fertilizer Market Report:

  • Impact of technological innovations on the solid phosphate fertilizer market
  • Growth strategies adopted by the main market players to meet the major challenges posed by the COVID-19 pandemic
  • Historical and current trends likely to impact solid Phosphate Fertilizers market dynamics
  • Assessment of the growth of various market segments during the forecast period
  • Regional and global presence of significant market players in the solid phosphate fertilizers market

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How PINK1, linked to familial Parkinson’s disease, activates in detail for the first time https://imphos.org/how-pink1-linked-to-familial-parkinsons-disease-activates-in-detail-for-the-first-time/ Fri, 31 Dec 2021 13:00:32 +0000 https://imphos.org/how-pink1-linked-to-familial-parkinsons-disease-activates-in-detail-for-the-first-time/ In a “world first”, Australian scientists report in detail what happens to the PINK1 protein when activated, helping to eliminate the “confusion” that has surrounded this support protein for cells including dopamine-producing neurons. Since the mutations of the PINK1 gene that codes for this protein are known to cause certain forms of familial Parkinson’s disease, […]]]>

In a “world first”, Australian scientists report in detail what happens to the PINK1 protein when activated, helping to eliminate the “confusion” that has surrounded this support protein for cells including dopamine-producing neurons.

Since the mutations of the PINK1 gene that codes for this protein are known to cause certain forms of familial Parkinson’s disease, the discovery could open up new avenues of treatment.

“Biotech and pharmaceutical companies are already considering this protein and pathway as a therapeutic target for Parkinson’s disease, but they’re flying a bit blindly. I think they’ll be really excited to see this amazing new structural information that our team was able to produce ”, David Komander, PhD, professor at the Walter and Eliza Hall Institute for Medical Research (WEHI) and lead author of the study , said in a press release.

The study, “PINK1 activation mechanism, ”Was published in the journal Nature in an unedited (but peer-reviewed) version to “give quick access to its findings”.

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Mitochondria are subcellular structures often referred to as the “powerhouse of the cell” because they are primarily responsible for the production of cellular energy. The PINK1 protein plays an essential role in mitophagy, the process used by cells to recycle damaged or dysfunctional mitochondria and replace them with new ones.

When the PINK1 protein is stabilized on the surface of mitochondria and is activated, it sends signals to other cellular components to initiate mitophagy.

In some forms of Parkinson’s disease, however, mutations in the PINK1 gene lead to a dysfunctional PINK1 protein, which alters mitophagy so that ultimately cells are not able to get enough energy to function as expected. This is believed to be a driving force behind the death of nerve cells in Parkinson’s disease associated with PINK1 mutations, and mitochondrial dysfunction has been strongly linked to Parkinson’s disease in general.

Despite the known role of the PINK1 protein in mitophagy, the details of what actually happens when the protein is activated – in terms of changes at the molecular level – were not clear.

“Numerous papers from labs around the world, including our own, have captured snapshots of the PINK1 protein. However, the differences between these snapshots in some ways fueled confusion about the protein and its structure, ”said Zhong Yan Gan, PhD student at WEHI and the study’s first author.

Gan and his colleagues used a new technique called cryogenic electron microscopy (cryo-EM) to observe the PINK1 protein in motion.

“This is the first time that we have used cryo-EM at WEHI to resolve the structure of small proteins such as PINK1,” said Alisa Glukhova, PhD, professor at WEHI and co-author of the study. “This revolutionary technique has only been available in the past five years, and… is a prime example of how innovative technologies can truly advance research and lead to transformative discoveries,” added Glukhova.

The researchers mainly used cryo-EM to take pictures of the PINK1 protein at different times before, during and after its activation. Then these individual snapshots were “put together” – a kind of stop-motion animation, according to Gan – to demonstrate the series of events by which PINK1 activates.

“We were then able to reconcile why all of those previous structural images were different – these were snapshots taken at different points in time because this protein was activated to perform its function in the cell,” Gan said. “There are tens of thousands of articles on this protein family, but visualizing how this protein comes together and changes in the process of activation is truly a world first.”

A notable finding from this work is that, when activated, PINK1 forms a dimer, a pairing of two proteins connected to each other that work in concert. Specifically, the dimer allows PINK1 proteins to attach phosphate groups – a chemical modification called autophosphorylation which is crucial for their activation.

Formation of the dimer is “essential for turning on or activating the protein to perform its function,” Gan said.

Another notable discovery is that, even when not in its “active” state, the PINK1 protein still retains kinase activity. In other words, its structure suggests that even inactive protein can have biochemical effects on other cellular components.

Scientists noted the need for further research to determine which substance (s) in the cell might interact with PINK1, and the functional consequences of these interactions.

“Our mechanical knowledge will likely aid efforts to exploit PINK1 as a drug target to stimulate mitophagy and treat” Parkinson’s disease, the team concluded.


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Solid Phosphate Fertilizer Market Size 2021-2028 by Types, Applications and Major Key Players – OCP, ICL, Coromandel International, CF Industries, Eurochem – Industrial IT https://imphos.org/solid-phosphate-fertilizer-market-size-2021-2028-by-types-applications-and-major-key-players-ocp-icl-coromandel-international-cf-industries-eurochem-industrial-it/ Wed, 29 Dec 2021 17:00:45 +0000 https://imphos.org/solid-phosphate-fertilizer-market-size-2021-2028-by-types-applications-and-major-key-players-ocp-icl-coromandel-international-cf-industries-eurochem-industrial-it/ The Global Solid Phosphate Fertilizer Market report is a perfect basis for people seeking comprehensive study and analysis of the Global Solid Phosphate Fertilizer Market. This report contains diverse study and information that will help you understand your niche and key market channel concentration in the global regional and global Solid Phosphate Fertilizers market. To […]]]>

The Global Solid Phosphate Fertilizer Market report is a perfect basis for people seeking comprehensive study and analysis of the Global Solid Phosphate Fertilizer Market. This report contains diverse study and information that will help you understand your niche and key market channel concentration in the global regional and global Solid Phosphate Fertilizers market. To understand the competition and take action based on your key strengths, market size, demand for current and future years, supply chain information, business concerns, competitive analysis, and pricing , as well as supplier information, will be presented to you. The report also contains information on the major market players, global solid phosphate fertilizer applications, its type, trends and overall market share.

To implement your business plan based on our detailed report, you will also receive complete and accurate forecasts as well as future projected figures. This will provide an overview of the market and help design solutions to leverage key profitable elements and gain market clarity to make strategic plans. The data in the report comes from various publications in our archives as well as from many reputable paid databases. Moreover, the data is gathered with the help of dealers, raw material suppliers and customers to ensure that the end result covers every detail regarding the global Solid Phosphate Fertilizer Market, making it a perfect tool for buyers. seriousness of this study.

Global Solid Phosphate Fertilizer Market: Competitive Landscape

The Global Solid Phosphate Fertilizers Market report includes information on product launches, sustainability, and outlook for major vendors, including: (OCP, ICL, Coromandel International, CF Industries, Eurochem, PotashCorp, Yara International ASA, Agrium, Phosagro, The Mosaic)

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Global Solid Phosphate Fertilizer Market: Segmentation

Global Solid Phosphate Fertilizer Market is split by type and application for the period 2021-2028, the growth among the segments provides accurate tricks and sales forecast by type and by application in terms of volume and value. This analysis can help you grow your business by targeting qualified niche markets.

By types

Diammonium Phosphate (DAP)
Monoammonium phosphate (PAM)
Superphosphate

By applications

Fertilizer industry
Agricultural culture

Global Solid Phosphate Fertilizers Market: Regional Analysis

All the regional segmentation has been studied on the basis of recent and future trends, and the market is forecast throughout the forecast period. Countries Covered in Regional Analysis of Global Solid Phosphate Fertilizer Market Report are United States, Canada, and Mexico in North America, Germany, France, United Kingdom, Russia, Italy , in Spain, in Turkey, in the Netherlands, in Switzerland, in Belgium and in the rest of Europe in Europe, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, China, Japan, India, South Korea, Rest of Asia-Pacific (APAC) Asia-Pacific (APAC), Saudi Arabia, United Arab Emirates, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) being part of the Middle East and Africa (MEA), and Argentina, Brazil and the rest of South America being part of South America.

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Main points covered by the table of contents:

Overview: Besides a detailed overview of the global solid phosphate fertilizers market, this segment provides an overview of the report to give an idea of ​​the nature and substance of the review study.

Analysis of the strategies of the main players: Market players can use this analysis to gain competitive advantage over their competitors in the global solid phosphate fertilizer market.

Study on the main market trends: This part of the report offers a more meaningful assessment of recent and future examples of the market.

Market Forecast: Buyers of this report will address accurate and approved valuations of all market sizes in terms of value and volume. The report further gives the use, creation, offerings, and different conjectures for the global Solid Phosphate Fertilizer market.

Analysis of local growth: All critical regions and countries have been covered in the report. Neighborhood review will help uplift players to exploit rejected common business areas, prepare express philosophies for target regions, and consider improving each regional market.

Segmental analysis: The report gives precise and solid conjectures about a portion of the pie of significant parts of the Global Solid Phosphate Fertilizers Market. Market members can use this review to pinpoint key interests in key development pockets of the market.

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Key questions answered in the report:

  • What will be the pace of development of the global solid phosphate fertilizer market?
  • What are the key factors driving the global solid phosphate fertilizer market?
  • Who are the main manufacturers in the market?
  • What are the outlets, the risks and the contours of the market?
  • What are the sales, revenue, and price analyzes of the major manufacturers of the global solid phosphate fertilizer market?
  • Who are the distributors, traders and dealers in the global Solid Phosphate Fertilizers market?
  • What are the opportunities and threats of the global solid phosphate fertilizer market facing the suppliers of the global solid phosphate fertilizer industries?
  • What are Deals, Revenue, and Value Reviews by Market Types and Uses?
  • What are the reviews of transactions, revenue and value by business line?

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Sorrento Announces Rapid COVISTIX COVID-19 Virus Antigen Test Detects Omicron Variant https://imphos.org/sorrento-announces-rapid-covistix-covid-19-virus-antigen-test-detects-omicron-variant/ Mon, 27 Dec 2021 19:43:27 +0000 https://imphos.org/sorrento-announces-rapid-covistix-covid-19-virus-antigen-test-detects-omicron-variant/ COVISTIX maintains its ability to detect the Omicron variant, in addition to detecting SARS-CoV-2 and all of its major variants of concern (VoC); COVISTIX has the potential to be a ‘best in class’ COVID-19 virus antigen rapid test: Comparative studies with all EUA approved COVID-19 virus antigen rapid detection assays have shown that COVISTIX significantly […]]]>
  • COVISTIX maintains its ability to detect the Omicron variant, in addition to detecting SARS-CoV-2 and all of its major variants of concern (VoC);
  • COVISTIX has the potential to be a ‘best in class’ COVID-19 virus antigen rapid test:
    • Comparative studies with all EUA approved COVID-19 virus antigen rapid detection assays have shown that COVISTIX significantly outperforms in terms of limit of detection (LOD) of live N-proteins and / or viruses of SARS- CoV-2 and its main VoCs; and
    • In a large clinical field study under real conditions for all, including asymptomatic patients, COVISTIX demonstrated approximately 20% higher sensitivity compared to a leading global brand (detailed results are available at: https: // www .medrxiv.org / content / 10.1101 / 2021.09.10.21263410v1);
  • COVISTIX is currently approved and marketed in Mexico, Brazil and is CE marked in Europe;
  • Sorrento is building a new US domestic production facility in San Diego, California with an automated assembly line targeting an initial capacity of six (6) million COVISTIX tests per month;
  • Sorrento is also in talks with several US states for incentive programs to further expand its manufacturing capacity in the US pending strong US and global demand for COVISTIX testing; and
  • By combining OEM and in-house manufacturing capabilities, Sorrento is positioning itself to deliver 30 million COVISTIX tests per month in the short term and grow to 50-100 million COVISTIX tests per month to meet accelerating global demand.

SAN DIEGO, December 27, 2021 (GLOBE NEWSWIRE) – Sorrento Therapeutics, Inc. (Nasdaq: SRNE, “Sorrento”) today announced that the first tests of COVISTIX on recombinant N proteins have demonstrated its ability to detect the variant Omicron, in addition to detecting the original SARS-CoV-2 virus and its other major VoCs such as delta and delta-plus strains. COVISTIX detection levels were similar for all variants. The ease of use and rapid detection of infection with Omicron was demonstrated by a recent case report of a Mexican patient infected with the Omicron variant first detected with COVISTIX within approximately 15 minutes of testing time. This result was confirmed a day later by RT-PCR and the sequence was verified a few days later as being an infection with Omicron.

In the laboratory, Sorrento also studied the ability of COVISTIX to detect the Omicron variant against other rapid COVID-19 virus antigen tests approved by the Emergency Use Authorization (EUA) and available in the trade. The first laboratory results show that COVISTIX was able to detect the Omicron N protein at a level significantly lower than that of other commercially available tests. With difficulty in detecting Omicron N protein at low levels, some of the rapid tests approved and marketed by the EUA may struggle to detect Omicron infection with reasonable sensitivity. False negative readings for asymptomatic infected patients could lead to a false sense of security and the inability to control outbreaks and perform normal social and business routines.

Sorrento currently has the capacity to produce 30,000,000 COVISTIX tests per month and is currently strengthening its manufacturing capacity in the United States. The company plans to have a fully automated assembly line capable of producing 6,000,000 COVISTIX units per month operational in the first quarter of 2022. Pending US and global demand, this capacity could potentially be increased to over 100 million. per month in 2022.

About Sorrento Therapeutics, Inc.

Sorrento is a clinical and commercial biopharmaceutical company developing new therapies to treat cancer, pain (non-opioid treatments), autoimmune diseases and COVID-19. Sorrento’s multimodal, multidimensional approach to cancer control is made possible by its extensive immuno-oncology platforms, including key assets such as fully human antibodies (“G-MAB ™ library”), immuno-therapies -cellular (“DAR-T ™”), antibody-drug conjugates (“ADC”) and oncolytic virus (“Seprehvec ™”). Sorrento is also developing antiviral therapies and potential coronavirus vaccines, including Abivertinib, COVI-AMG ™, COVISHIELD ™, COVI-MSC ™ and COVIDROPS ™; and diagnostic test solutions, including COVITRACK ™ and COVISTIX ™.

Sorrento’s commitment to life-enhancing therapies is also demonstrated by our efforts to advance a first-class, non-opioid small-molecule pain management (TRPV1 agonist), resiniferatoxin (“RTX”) and SP-102 (10 mg, dexamethasone sodium phosphate viscous gel) (SEMDEXA ™), a new viscous gel formulation of a corticosteroid widely used for epidural injections to treat lumbosacral radicular pain, or sciatica, and for market ZTlido® (lidocaine topical system) 1.8% for the treatment of postherpetic neuralgia. RTX has completed a Phase 1B trial for intractable pain associated with cancer and a Phase 1B trial in patients with osteoarthritis. SEMDEXA is in a pivotal phase 3 trial for the treatment of lumbosacral radicular pain, or sciatica. ZTlido® was approved by the FDA on February 28, 2018.

For more information, visit www.sorrentotherapeutics.com.

Forward-looking statements

This press release and all statements made for and during any presentation or meeting contain forward-looking statements relating to Sorrento Therapeutics, Inc., under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995. and subject to risks and uncertainties. which could cause actual results to differ materially from those projected. Forward-looking statements include statements about COVISTIX, including its sensitivity and specificity, limit of detection and the rate at which COVISTIX provides results or is able to provide results; the ability of COVISTIX to detect SARS-CoV-2 and its major variants of concern (VoC), including the Omicron variant; the performance capabilities of COVISTIX, including against the rapid detection tests for COVID-19 virus antigens approved by the EUA; Sorrento’s current and planned future manufacturing capacity for COVISTIX, including the expected timeframe for capacity expansion and the potential for production expansion in one or more US states based on state incentives; and Sorrento’s potential position in the diagnostic industry. Risks and uncertainties that could cause our actual results to differ materially and adversely from those expressed in our forward-looking statements, include, without limitation: risks relating to the technologies and prospects of Sorrento and its subsidiaries, affiliates and partners and collaborations with partners, including, but not limited to, risks associated with performing additional studies and seeking regulatory approval for COVISTIX, including the timing of receipt of such approval; conduct and receive the results of clinical studies; clinical development risks, including risks relating to the progress, timing, costs and results of clinical studies and product development programs; risk of difficulties or delays in obtaining regulatory approvals; the risks that the results of a clinical study will not meet all or part of the parameters of a clinical study and that the data generated from these studies may not support a regulatory submission or approval; the risks that the results of previous trials, studies and trials will not be reproduced in future studies and trials; business risks associated with COVISTIX, including expectations regarding demand and market acceptance of COVISTIX; expectations regarding the maintenance and strengthening of its relationships with partners and customers; the risks of manufacturing and supplying COVISTIX nationally and globally; risks associated with using the expertise of its employees, subsidiaries, affiliates and partners to assist the company in the execution of its COVID-19 product candidate strategies; risks associated with the global impact of COVID-19; and other risks which are described in Sorrento’s most recent periodic reports filed with the Securities and Exchange Commission, including Sorrento’s annual report on Form 10-K for the fiscal year ended December 31, 2020, and subsequent quarterly reports on Form 10-Q filed with the Securities and Exchange Commission, including the risk factors set out in those documents. Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release, and we assume no obligation to update any forward-looking statements contained in this press release, unless the law requires it.

Media contact and investor relations
Dorman Followwill
Email: mediarelations@sorrentotherapeutics.com

Sorrento® and the Sorrento logo are registered trademarks of Sorrento Therapeutics, Inc.

G-MAB ™, DAR-T ™, Seprehvec ™, SOFUSA ™, COVI-AMG ™, COVISHIELD ™, COVIDROPS ™, COVI-MSC ™, COVITRACK ™ and COVISTIX ™ are trademarks of Sorrento Therapeutics, Inc.

SEMDEXA ™ is a trademark of Semnur Pharmaceuticals, Inc.

ZTlido® is a registered trademark owned by Scilex Pharmaceuticals Inc.

All other trademarks are the property of their respective owners.

© 2021 Sorrento Therapeutics, Inc. All rights reserved.

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Compensate for a vitamin D deficiency https://imphos.org/compensate-for-a-vitamin-d-deficiency/ Sat, 25 Dec 2021 18:00:00 +0000 https://imphos.org/compensate-for-a-vitamin-d-deficiency/ Vitamin D is a fat soluble vitamin that helps calcium absorption in the gut and maintains adequate serum calcium and phosphate for healthy bones, teeth, and muscles. Vitamin D deficiency is a silent and neglected global public health problem today. Almost a billion people around the world suffer from vitamin D deficiency or insufficiency. Symptoms […]]]>

Vitamin D is a fat soluble vitamin that helps calcium absorption in the gut and maintains adequate serum calcium and phosphate for healthy bones, teeth, and muscles. Vitamin D deficiency is a silent and neglected global public health problem today. Almost a billion people around the world suffer from vitamin D deficiency or insufficiency.

Symptoms of vitamin D deficiency have been linked to different health problems, including heart disease, depression, and cancer. The signs that you are not getting enough vitamin D are: softening of the bones of fractures, fatigue and general weakness, muscle cramps, pain in joints and bones, trouble healing wounds, dizziness, anxiety, hair loss.

For all the latest news, follow the Daily Star’s Google News channel.

To fill the vitamin D deficiency, the following measures can be taken:

• Go out in the sun

• Eat foods rich in vitamin D every day. for example: mushrooms, liver, meat, fish, liver oil, shrimp, egg yolk, oatmeal.

• Take supplements while consulting doctors

• Regularly test the blood for 25-hydroxy vitamin D.

• Spending enough time in the sun and eating foods rich in vitamin D is the best way to get a daily dose of vitamin D. Only eating foods rich in vitamin D is insufficient to meet your daily dose.

Check your vitamin D level twice a year and talk to your healthcare professional before taking a vitamin D supplement.

The author is a neurodynamic specialist and clinical physiotherapist at BRB Hospital Ltd.
Email: ranacrpphysio@gmail.com


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Kentucky tornado: Feared dead cat found alive in rubble nine days later https://imphos.org/kentucky-tornado-feared-dead-cat-found-alive-in-rubble-nine-days-later/ Fri, 24 Dec 2021 06:56:19 +0000 https://imphos.org/kentucky-tornado-feared-dead-cat-found-alive-in-rubble-nine-days-later/ A cat believed to have been killed in the deadly Kentucky tornado earlier this month was found alive on Sunday. The cat named Madix was owned by Sonny “Hoot” Gibson, a rental business owner in Mayfield Kentucky. On the night of December 10 to 11, thirty-seven tornadoes were reported in six states from Friday evening […]]]>

A cat believed to have been killed in the deadly Kentucky tornado earlier this month was found alive on Sunday.

The cat named Madix was owned by Sonny “Hoot” Gibson, a rental business owner in Mayfield Kentucky.

On the night of December 10 to 11, thirty-seven tornadoes were reported in six states from Friday evening through Saturday morning. At least 14 people have been confirmed dead in Illinois, Tennessee, Arkansas and Missouri.

Kentucky was the hardest hit with at least 74 dead and over 100 injured.

Mr Gibson said he was at home when the worst tornado in Kentucky history hit Mayfield and he was unable to make it to his office where his office cat was, reported WTVF.

With his office destroyed, Mr. Gibson tried to search for the cat but gave up after two or three days.

He said he had given up hope that his cat would be alive after the tornadoes that left behind massive destruction in Kentucky and in particular Mayfield.

“I don’t know how anything survived not only the tornado but the destruction that accompanied it,” he told The Associated Press.

On Sunday afternoon, Mr Gibson was standing in the rubble of his old office when he said he heard a low noise.

“I thought I heard a meow, and I thought my mind was playing tricks on me so I called out his name, and he meowed again,” he said.

Mr. Gibson called a few employees and together they looked through the rubble to locate the noise and eventually found Madix. The cat was stuck in a hole under the rubble.

While the cat was thirsty and hungry, being under the rubble for nine days, Mr Gibson said he suffered no injuries.

“It was just an amazing feeling to put him in my arms,” Mr. Gibson said. “If the cats actually have nine lives, he’s probably used about eight in that nine-day period. ”

The cat’s survival story has become popular in Mayfield, a community struggling to get back on their feet after the devastation of the tornado.

“It is a blessing for people to hear the story so that they can understand it and realize that great things can come out of terrible situations. If this is uplifting for a person, then Madix has served his purpose on this planet, ”Mr. Gibson said.


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Coatings Pretreatment Market Size by Growth Share, Driving Factors, Key Segments and Regional Analysis – mainlander.nz https://imphos.org/coatings-pretreatment-market-size-by-growth-share-driving-factors-key-segments-and-regional-analysis-mainlander-nz/ Wed, 22 Dec 2021 10:17:00 +0000 https://imphos.org/coatings-pretreatment-market-size-by-growth-share-driving-factors-key-segments-and-regional-analysis-mainlander-nz/ The market is analyzed on the basis of regions and the competitive landscape of each region is mentioned. The regions covered in the study include North America (United States, Canada and Mexico), Europe (Germany, France, United Kingdom, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia), Middle East […]]]>

The market is analyzed on the basis of regions and the competitive landscape of each region is mentioned. The regions covered in the study include North America (United States, Canada and Mexico), Europe (Germany, France, United Kingdom, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia), Middle East and Africa (Saudi Arabia, United Arab Emirates, Egypt, Nigeria and South Africa). This information helps to design strategies and create new opportunities to achieve exceptional results.

The research offers an in-depth analysis of the major players active in the global coating pretreatment market including Chemetall GmbH (Germany), AkzoNobel NV (Netherlands), Axalata Coating System LLC (US), PPG Industries (US) ), Henkel AG & Co. KGgA (Germany), Sherwin-Williams Company (United States) and Nippon Paints Co. Ltd. (Japan).

Request Sample PDF Report: https://www.alliedmarketresearch.com/request-sample/14133

The research offers detailed segmentation of the global coatings pretreatment market. Key segments analyzed in the research include type, process, shell material, application, end user, and geography. An in-depth analysis of the sales, revenue, growth rate and market share of each type, process, shell material, application, and end-user for the historical period and forecast period are offered with the help of tables .

Allied Market Research released a new report titled “Coating Pretreatment Market: By Product Type (Pre-Paint Conversion Coatings (Iron Phosphate, Zinc Phosphate, Chromate, Chromate Free, Stripping Media), Anticorrosive Coatings, Metalworking Fluids, Cleaners, Final Seals (Chromium Phosphate, Corrosion Inhibitors)), By Metal Type (Steel, Aluminum), By Application (Building & Construction, Automotive & Transportation, Home Appliances) Global Opportunity Analysis & Forecast Industry, 2021-2030 ”The report offers an in-depth analysis of key growth strategies, drivers, opportunities, key segment, Porter’s five forces analysis and competitive landscape. This study is a useful source of information for market players, investors, VPs, stakeholders and new entrants to gain an in-depth understanding of the industry and determine the steps to be taken to gain a competitive advantage. .

The report offers key drivers that are propelling the growth of the global Coatings Pretreatment market. This information helps market players design strategies to gain market presence. The research also highlighted the constraints of the market. Opportunity information is mentioned to help market players take further action by determining potential in untapped regions.

A detailed analysis of operational business segments, product portfolio, business performance and key strategic developments is offered in the research. Major market players analyzed in the report include Celanese Corporation. These players have adopted various strategies including expansions, mergers and acquisitions, joint ventures, new product launches and collaborations to gain a solid position in the industry.

For Purchase Inquiry: https://www.alliedmarketresearch.com/purchase-enquiry/14133

Key Benefits:

• The report provides qualitative and quantitative analysis of the current Coatings Pretreatment market trends, forecast and market size from 2021 to 2030 to determine new opportunities.
• Porter’s Five Forces Analysis highlights the power of buyers and suppliers to enable stakeholders to make strategic business decisions and determine the level of competition in the industry.
• The main impact factors and the main pockets of investment are highlighted in the research.
• The main countries of each region are analyzed and their contribution to income is mentioned.
• The positioning segment of market players provides an understanding of the current position of market players active in the coatings pretreatment market.

Main report offerings:

• Main Drivers and Opportunities: Detailed analysis of drivers and opportunities in different segments for strategy development.
• Current Trends and Forecasts: Comprehensive analysis of the latest trends, developments and forecasts for the coming years in order to take the next steps.
• Segment Analysis: Analysis of each segment and driving factors along with revenue forecast and growth rate analysis.
• Regional Analysis: In-depth analysis of each region helps market players to design expansion strategies and leap forward.
• Competitive Landscape: Detailed information about each of the major market players to define the competitive scenario and take action accordingly.

Request for Personalization: https://www.alliedmarketresearch.com/request-for-customization/14133

About Us

Allied Market Research (AMR) is a Portland, Oregon-based market research and business consulting firm of Allied Analytics LLP. AMR offers market research reports, business solutions, consulting services and market intelligence across 11 verticals. Adopting in-depth research methodologies, AMR helps to help clients make strategic business decisions and achieve sustainable growth in their market areas. We are staffed with qualified analysts and experts and have extensive experience working with many Fortune 500 companies and small and medium enterprises.


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The science of everything https://imphos.org/the-science-of-everything/ Mon, 20 Dec 2021 21:00:49 +0000 https://imphos.org/the-science-of-everything/ By Mike Warren MARSHFIELD – A unique science class allows students at Marshfield High School to analyze the world around them. Students in Amy Fassler’s Advanced Placement Environmental Science class had the opportunity to present their most recent findings in an after-school “poster session” on December 15 for fellow teachers and MHS students. “The project-based […]]]>

By Mike Warren

MARSHFIELD – A unique science class allows students at Marshfield High School to analyze the world around them.

Students in Amy Fassler’s Advanced Placement Environmental Science class had the opportunity to present their most recent findings in an after-school “poster session” on December 15 for fellow teachers and MHS students.

“The project-based learning model has really allowed students to delve into a subject that interests them,” said Fassler. “The students really enjoyed listening to other students talk about their project and ask them questions. The students think that the projects give them a good opportunity to connect a lot of different subjects in their study of environmental science.

At least one of those subjects asked junior Monet Veers to examine the invasive giant hogweed she found right next to the central farm field of a Wisconsin relative.

Carly Winder and Richard Gui watch as their classmates Will Jepsen and Henry Johnson present the results of their AP Environmental Science class project “How does the area of ​​a habitat influence species diversity?” December 15 at Marshfield High School.

“We have what we think is probably giant hogweed just down the road from my house. We counted a few hundred plants, ”she said.

According to the poster that Veers prepared for his presentation to the class, “The land adjacent to the potentially infested area is being used for agriculture. Since the presence of giant hogweed decreases the overall health of the soil, identification and control will be crucial for the region’s farmers and their crops.

Veers said giant hogweed is not a picnic for humans either.

“The sap of the giant hogweed will get on your skin, and you will be fine until you get out in the sun. The sun hits the sap and that can give you third degree burns, ”she added.

The United States has now classified the invasive plant as a noxious weed.

Fassler’s “science experiment” led other students to study the environment just beyond their classroom walls.

In a project called ‘War on Marine Life’, juniors Sophia Soskos and Julia Kumm “tested the levels of phosphate and nitrate in the wetland pond behind our Marshfield High School and Braem Park Creek”. according to Soskos.

“We also tested the dissolved oxygen levels,” Kumm added. “We are finding that when there are more nutrients, like phosphates and nitrates, in the water, there will be less dissolved oxygen, and this is due to eutrophication, which is an excess of nutrients in the water. the water. This causes algae blooms. When algae die off, bacteria consume dissolved oxygen and kill animals and marine life in the water system.

Soskos and Kumm were able to correlate what they found locally with an excessive runoff of nitrates and phosphates in the Gulf of Mexico, causing “dead zones” with a lack of dissolved oxygen, which now has a direct economic impact. on a decline in seafood production and tourism, not to mention an explosion of harmful toxins from algae blooms that pose a risk to human health.

The second year project Carly Winder asked the question “What kills bees?” “

“A combination of Varroa mites, fungicide and habitat loss,” Winder said as he explained his project and poster to a group of parents and teachers. Winder has studied the decline in the honey bee population, both nationally and internationally, and possible ways to reverse the trend.

Another group of students broached the idea of ​​tracing ivory to prevent poaching of African elephants.

“Our experiment was based on a previous experiment in which they had taken ivory samples and performed DNA analyzes to locate higher than normal elephant poaching rates,” said Ruhi Shah. “From there, they were able to find solutions to potentially limit the rate of increase. “

Shah added that the group’s main question for the experiment was how tracking the origin of ivory in Africa could prevent future elephant poaching.

“The main identifiable variable for differentiating ivory is called short tandem repeats,” according to a member of the Sydney Newmier group. “When we looked at the DNA, we separated them into different DNA fragments to determine where the ivory came from. So those short tandem repeats are non-coding DNA segments, and so it is. that they determine the difference between elephant species and their origin.

Group third member Ava Sainterme added: “Our overall goal was to use this DNA to compare these fragments to those in the existing database. We used this to track the elephant population and what country they came from, to determine where the highest poaching rates were. “

The Henry Johnson and Will Jepsen duo examined how habitat area influences species diversity.

“As humans use more land, the amount of resources available to animals decreases,” according to their project poster. “Our results may help conservationists plan and create sufficiently large habitat islands.”

“They’ve all done two projects so far this year,” says Fassler, “and they’ll probably complete six in total.

“As an instructor, it was great for me to work with students to ask good science questions, design an experiment, and help them analyze their data. “


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