Phosphate Study – IMPHOS http://imphos.org/ Fri, 24 Sep 2021 20:00:25 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://imphos.org/wp-content/uploads/2021/08/IMPHOS-icon-150x150.jpg Phosphate Study – IMPHOS http://imphos.org/ 32 32 Does it improve sexual performance? https://imphos.org/does-it-improve-sexual-performance/ https://imphos.org/does-it-improve-sexual-performance/#respond Fri, 24 Sep 2021 20:00:25 +0000 https://imphos.org/does-it-improve-sexual-performance/ Erectile dysfunction (ED) and premature ejaculation (PE) are relatively common. While there are several prescription drugs that can help, there are also many over-the-counter (OTC) supplements that promise the same effects. One of these supplements is VigRX Plus. While it doesn’t require a prescription, it does promise to provide harder erections and increased stamina, and […]]]>

Erectile dysfunction (ED) and premature ejaculation (PE) are relatively common. While there are several prescription drugs that can help, there are also many over-the-counter (OTC) supplements that promise the same effects.

One of these supplements is VigRX Plus. While it doesn’t require a prescription, it does promise to provide harder erections and increased stamina, and it claims to be clinically proven with no known side effects.

But the product’s health claims are somewhat misleading, and there isn’t a lot of safety or efficacy data to back up its claims.

Below, we’ll explore the research behind the supplement’s claims. We will also highlight reliable alternatives for enhanced sexual experiences.

VigRX Plus is marketed as a male enhancement pill fortified with what the company calls “potent aphrodisiacs”.

In addition to the stated benefits like increased stamina and harder erections, VigRX also assures users of faster recovery and increased satisfaction from sexual encounters.

It is mainly intended for those who know:

Here are the active ingredients listed in each VigRX Plus pill:

  • Korean red ginseng. Reputed to have benefits, like reducing inflammation and increasing energy, ginseng has also been popularly recommended for people with erectile dysfunction.
  • Dwarf palm. This shrub is renowned for treating everything from hair loss and migraines to low testosterone, although there isn’t enough research to back up these claims.
  • Hawthorn berry. These popular berries are rich in antioxidants.
  • Ginkgo biloba leaf. Ginkgo biloba can improve blood circulation – an important characteristic for long-lasting erections – and a Revision 2021 noted its potential as a natural inhibitor of phosphodiesterase type 5 (PDE5). Prescription drug PDE5 inhibitors, such as Viagra and Cialis, are commonly used to treat erectile dysfunction.
  • Damiana leaf. This herb has long been considered an aphrodisiac, but evidence for its effectiveness is lacking.
  • Tribulus terrestris vine. Said to improve libido, research on tribulus terrestri is mixed.
  • Catuaba bark. This herb is included in some supplements to help reduce fatigue.
  • Muira puama bark. It is a type of bush native to the Amazon.
  • Cuscuta seed extract. Also known as dodders, Cuscuta is a group of parasitic plants.
  • Horny goat weed. Horny goat weed is believed to be helpful for erectile dysfunction, but the evidence is mixed.
  • Bioperine. This patented ingredient is made from black pepper and contains a high amount of piperine, a natural compound of black pepper. Bioperine is particularly known to be a bioavailability activator, which means it can help increase the absorption of other vitamins and minerals.

You’ll also find inactive ingredients, like dicalcium phosphate, cellulose, and red food coloring, on the list.

You may wish to delay ordering this supplement. While there is limited evidence on how effective some of these ingredients are for sexual health, there isn’t enough quality research to say that they actually work.

In addition, a 2010 study out of 85 people with erectile dysfunction found no statistically significant effect of VigRX Plus compared to placebo.

This contrasts with VigRX’s claims. The brand claims that its study of 75 men found that VigRX Plus caused increased sexual satisfaction, erection ability, libido, and more.

However, this study was conducted by a research company and does not appear to have been published in a peer-reviewed journal.

VigRX Plus consists primarily of herbal supplements, but that doesn’t necessarily mean it’s safe.

For starters, it’s unclear whether the company regularly tests their product for purity and quality. There is no third party testing information on the VigRX site, and it does not appear to be NSF certified.

Likewise, information on safety, efficacy and side effects is lacking. Although the brand is linked to a safety and efficacy study at the company’s site, this is an animal study from over 10 years ago, and she notes that others studies are needed to fully assess the long-term safety of the product.

Additionally, two animal studies of side effects published on the VigRX website were performed by a research group in 2005 and do not appear to have been published in a peer-reviewed journal.

The first study notes that a dose of 30 milligrams (mg) per kilogram (kg) of body weight per day resulted in a significant decrease in liver and kidney weight, while the second study found no change in organ at a dose of 15 mg / kg. /daytime.

Additionally, there is some evidence that certain ingredients in VigRX can cause side effects in some people.

For example, insomnia is a potential side effect of ginseng, and saw palmetto can cause digestive issues or headaches. Ginkgo biloba can also cause side effects and interact with certain medications, such as blood thinners.

If you still want to try VigRX Plus, talk to your doctor first. This is especially important if you are taking other supplements or medications.

The makers of VigRX Plus recommend taking it daily. Each box is a one month supply with a cost of around $ 90. If you buy more than one box, the price per box decreases.

VigRX appears to have a clean record when it comes to security and legal compliance.

The brand is part of Leading Edge Health Inc, an organization founded in 2002. The company has not received any warning letters from the Food and Drug Administration (FDA). The company is accredited by the Better Business Bureau and has an A + rating within the organization.

If you are experiencing erectile dysfunction, difficulty ejaculation, or problems with libido, there are other treatments you may want to explore.

ED treatments

Commonly prescribed prescription drugs for erectile dysfunction include:

  • sildenafil (Viagra)
  • avanafil (Stendra)
  • tadalafil (Cialis)
  • vardenafil (Levitra)

There are other options, like:

PE treatments

Common treatments for PE include:

Libido

If you want to increase your libido, you can try any of these tips.

Does VigRX Plus work?

While VigRX is claimed to improve stamina, libido, and sexual satisfaction, there is very little scientific support for these claims.

In addition to a study of VigRX confirming its effectiveness, an external review found that the drug was no more effective than a placebo.

Is VigRX Plus safe?

VigRX Plus contains herbal supplements, but that doesn’t necessarily mean it’s safe.

It is best to consult a doctor before trying a new supplement, especially if you are currently taking other supplements or medications.

Is VigRX Plus FDA Approved?

No. The FDA does not approve dietary supplements like VigRX Plus.

How much does VigRX cost?

A one month supply of VigRX costs around $ 90. However, the more boxes you buy, the less each box costs.

VigRX Plus is an over-the-counter supplement believed to increase libido and sexual satisfaction and provide harder erections. However, there isn’t much evidence to back up these claims.

Although the supplement contains mostly herbs, it is best to speak with your doctor before trying it or any other supplement.


Courtesy of Beth Plumptre

Elizabeth Plumptre is a freelance health and wellness writer. She has spent the past 4 years helping brands like Hims, MindBodyGreen and Prose create content that resonates with diverse readers. You can discover more of his work by visiting bethwrotethat.com.


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Exclusive analysis of the global specialty fertilizers market by future demands, current scenario and forecast to 2030 https://imphos.org/exclusive-analysis-of-the-global-specialty-fertilizers-market-by-future-demands-current-scenario-and-forecast-to-2030/ https://imphos.org/exclusive-analysis-of-the-global-specialty-fertilizers-market-by-future-demands-current-scenario-and-forecast-to-2030/#respond Fri, 24 Sep 2021 11:02:09 +0000 https://imphos.org/exclusive-analysis-of-the-global-specialty-fertilizers-market-by-future-demands-current-scenario-and-forecast-to-2030/ The 2021-2030 global research report on ‘Global Specialty Fertilizers Market’ is a specialized and comprehensive study of the Mental Health Software industry with emphasis on the global market trend. Additionally, the report provides information on global Specialty Fertilizers market size, assessment of market share, growth, cost structure, capacity, revenue, major players, and forecast for 2030. […]]]>

The 2021-2030 global research report on ‘Global Specialty Fertilizers Market’ is a specialized and comprehensive study of the Mental Health Software industry with emphasis on the global market trend. Additionally, the report provides information on global Specialty Fertilizers market size, assessment of market share, growth, cost structure, capacity, revenue, major players, and forecast for 2030. This report also provides the overall study of the global Specialty Fertilizers market share with all its aspects influencing the market growth. This report is a comprehensive quantitative analysis of the Mental Health Software industry and provides data for strategizing to increase the growth and efficiency of the global Specialty Fertilizer Market.

Some of the Major Players Featured in the Global Specialty Fertilizers Market:

Mosaic Company, Agrium Inc, Yara International, Haifa Chemicals, Atlantic Gold Corp, Art Wilson Co., Eurochem

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Before sowing, special fertilizers are mixed with the soil. This fertilizer contains essential nutrients and controls the amount of moisture in the soil, like a protective layer. Special fertilizers speed up nutrient acceleration, reduce potential nutrient loss, and reduce toxicity caused by high ion concentrations. They serve as binders to improve insecticide delivery and prevent leaching. Various special fertilizers include potassium sulfate, DAP, phosphoric acid, monoammonium phosphate, UAN, potassium nitrate, ammonium nitrate, monopotassium phosphate, calcium nitrate, urea, potassium chloride and ammonium sulfate.

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Objectives of the study report on Global Specialty Fertilizers Market:

  • To analyze and study the size, value, current market status, and forecast (2021-2030) of the Global Specialty Fertilizers Market
  • To analyze the major key players in the regions of the world, study the value and market share of the major players in these regions.
  • Focuses on the key market share of the global Specialty Fertilizers market and strategies for growth and development in the future.
  • Focuses on the analysis of the Global Specialty Fertilizers Market by the market competition landscape, the SWOT analysis.
  • To analyze the potential and advantages of the global market and key regions, opportunities and challenges, restraints and risks.
  • Analyze market opportunities for stakeholders by identifying high growth segments.
  • provides information and estimates the strategies of the main key players in the industry.

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Global Specialty Fertilizer Market Segmentation:

By type of crop

    • Cereals & Oilseeds
    • Fruits and vegetables
    • Lawns and ornamental plants
    • Others (legumes, sugar crops, fiber crops and plantation crops)

By type

    • Water soluble
    • Fertilizers
    • Slow and controlled release fertilizer
    • Fertilizers for micronutrients and secondary nutrients
    • Bio-stimulant
    • Fertilizers
    • Stabilized Fertilizers

By region

    • North America
      • we
      • Rest of North America
    • Europe
      • France
      • Great Britain
      • Spain
      • Germany
      • Italy
      • The rest of europe
    • Asia Pacific
      • China
      • Japan
      • India
      • South East Asia
      • Rest of Asia-Pacific
    • Middle East and Africa
      • GCC countries
      • South Africa
      • Rest of Middle East and Africa
    • Latin America
      • Brazil
      • Rest of Latin America

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Phosphate Fertilizer Market Size, Forecast and Major Companies – Yara International ASA, The Mosaic Company, Israel Chemical Ltd., CF Industries Holdings Inc., Coromandel International Limited, The OCP Group, PhosAfro PJSC https://imphos.org/phosphate-fertilizer-market-size-forecast-and-major-companies-yara-international-asa-the-mosaic-company-israel-chemical-ltd-cf-industries-holdings-inc-coromandel-international-limited-the-oc/ https://imphos.org/phosphate-fertilizer-market-size-forecast-and-major-companies-yara-international-asa-the-mosaic-company-israel-chemical-ltd-cf-industries-holdings-inc-coromandel-international-limited-the-oc/#respond Thu, 23 Sep 2021 18:46:48 +0000 https://imphos.org/phosphate-fertilizer-market-size-forecast-and-major-companies-yara-international-asa-the-mosaic-company-israel-chemical-ltd-cf-industries-holdings-inc-coromandel-international-limited-the-oc/ Sample download request Need for customization Price and purchase options New Jersey, United States, – The Phosphate Fertilizer Market report contains the most basic information on the market. This comprehensive report offers insights into the market, models and drivers of business growth. It also includes Phosphatic Fertilizer market share, sales volume and education charts. He […]]]>

New Jersey, United States, – The Phosphate Fertilizer Market report contains the most basic information on the market. This comprehensive report offers insights into the market, models and drivers of business growth. It also includes Phosphatic Fertilizer market share, sales volume and education charts. He was able to combine important and additional information, such as commitments from market leaders, into a well-designed report. The Phosphate Fertilizers Market report is an essential view of strategies and information. It is mainly aimed at business leaders. The primary objective of this Phosphate Fertilizer report is to provide industry knowledge and help our clients achieve natural growth in their respective fields. The Phosphate Fertilizers report also shows a new upward trend which includes market conditions and market forecast 2021-2028.

The phosphate fertilizer market was valued at USD 64.45 billion in 2020 and is expected to reach USD 84.05 billion by 2028, registering a CAGR of 3.38% from 2021 to 2028.

This study presents the principles of the Phosphate Fertilizer market: regional definitions and analyzes, review of software and activities, sector strategies and guidelines, product specifications, production methods, price agreements, etc. The report ends with a SWOT Assessment of Phosphate Fertilizers, Investment Feasibility Assessment and Return on Investment Assessment.

The report has conducted extensive research on the market segments and sub-segments and clarified which market segment will dominate the market during the forecast period. To assist clients in making informed decisions about company investment plans and strategies in the Phosphate Fertilizer market, the report involves in-depth information regarding regional market performance and competitive analysis.

The report covers an in-depth analysis of the major market players in the market, along with their business overview, expansion plans, and strategies. The major players studied in the report include:

Yara International ASA, Israel Chemical Ltd., The Mosaic Company, CF Industries Holdings Inc., Coromandel International Limited, The OCP Group, PhosAfro PJSC, Sociedad Quimica y Minera de Chile SA, Nutrien Ltd, Koch Industries Inc.

Segmentation of the phosphate fertilizer market

Phosphate Fertilizer Market, By Product Type

• Diammonium phosphate
• Monoammonium phosphate
• Simple superphosphate
• Triple superphosphate
• Others

Phosphate Fertilizer Market, By Crop Type

• Cereals and cereals
• Oilseeds
• Fruits and vegetables
• Others

Scope of Phosphate Fertilizers Market Report

Report attribute Details
Market size available for years 2021 – 2028
Reference year considered 2021
Historical data 2015 – 2020
Forecast period 2021 – 2028
Quantitative units Revenue in millions of USD and CAGR from 2021 to 2028
Covered segments Types, applications, end users, etc.
Cover of the report Revenue forecast, company ranking, competitive landscape, growth factors and trends
Regional scope North America, Europe, Asia-Pacific, Latin America, Middle East and Africa
Scope of customization Free customization of the report (equivalent to 8 working days for analysts) with purchase. Add or change the scope of country, region and segment.
Price and purchase options Take advantage of personalized shopping options to meet your exact research needs. Explore purchasing options

Geographic segment covered in the report:

The Phosphate Fertilizers report provides information about the market area, which is further subdivided into sub-regions and countries / regions. In addition to the market share in each country and sub-region, this chapter of this report also contains information on profit opportunities. This chapter of the report mentions the market share and growth rate of each region, country and sub-region during the estimated period.

  • The Middle East and Africa (GCC countries and Egypt)
  • North America (United States, Mexico and Canada)
  • South America (Brazil etc …)
  • Europe (Turkey, Germany, Russia UK, Italy, France, etc.)
  • Asia Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia and Australia)

Key questions answered in the report:

  • Who are the main global players in this phosphate fertilizer market?
  • What is their company profile, their product information, their contact details?
  • What was the global market status of the market?
  • What was the capacity, production value, cost and profit of the market?
  • What are the projections of the global industry taking into account the capacity, output and production value?
  • What will the cost and profit estimate be?
  • What will be the market share, supply and consumption?
  • What is the market chain analysis by upstream commodity and downstream industry?
  • What are the market dynamics of the market?
  • What are the challenges and opportunities?
  • What should be the entry strategies, the countermeasures to the economic impact, the marketing channels for the industry?

Visualize Phosphate Fertilizer Market Using Verified Market Intelligence: –

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Magnesium Phosphate market 2021: global size, share, trends, growth, revenue, segmentation, regional forecast to 2028 https://imphos.org/magnesium-phosphate-market-2021-global-size-share-trends-growth-revenue-segmentation-regional-forecast-to-2028/ https://imphos.org/magnesium-phosphate-market-2021-global-size-share-trends-growth-revenue-segmentation-regional-forecast-to-2028/#respond Wed, 22 Sep 2021 20:56:14 +0000 https://imphos.org/magnesium-phosphate-market-2021-global-size-share-trends-growth-revenue-segmentation-regional-forecast-to-2028/ “The global magnesium phosphate market is expected to reach US $ 1.79 billion by forecast year 2028” The Magnesium Phosphate market size is expected to grow from US $ 1.12 billion in 2020 to US $ 1.79 billion by 2028, at a CAGR of 6.0%. The market report ‘Magnesium Phosphate Market by Products (Dimagnesium Phosphate, […]]]>

“The global magnesium phosphate market is expected to reach US $ 1.79 billion by forecast year 2028”

The Magnesium Phosphate market size is expected to grow from US $ 1.12 billion in 2020 to US $ 1.79 billion by 2028, at a CAGR of 6.0%.

The market report ‘Magnesium Phosphate Market by Products (Dimagnesium Phosphate, Monomagnesium Phosphate, and Trimagnesium Phosphate), End Users (Food and Beverage, Pharmaceuticals, Animal Feed, Fertilizer, and Drinking Water Treatment) and region – Forecast until 2028 ”. The Magnesium Phosphate market is growing at a CAGR of 6.0% by 2028, owing to increasing demand from end-use industries.

We offer 15% customization to add in the report at no additional cost. To learn more, post your query here: https://www.strategymrc.com/report/magnesium-phosphate-market/request-sample

On the basis of end user, the food and beverage segment is expected to grow at the highest CAGR segment during the study period. On the basis of end user, the market is categorized into food and beverage, pharmaceutical, animal feed, fertilizer, and drinking water treatment. . The food and beverage segment is considered to be the fastest growing segment due to factors such as reducing the risk of diabetes, heart disease and hypertension, increasing demand in the industry baking and the maintenance of mineral balance and the regulation of enzymatic activity.

By geography, Asia-Pacific is expected to dominate the market Based on geography, the market is segmented into North America, Europe, Asia-Pacific, South America, Middle East, and Africa. Asia-Pacific enjoys a dominant position in the magnesium phosphate market due to the increase in population in the region and the growing emphasis and support from the government on training farmers to improve plant growth. .

Browse the full report with 96 data tables and over 16 figures here: https://www.strategymrc.com/report/magnesium-phosphate-market/toc

The main players in this market are American Elements, Anmol Chemicals Group, Celtic Chemicals, Hap Seng, Hindustan Phosphate, Innophos Holdings, Jost Chemical, Manus Aktteva Biopharma, Nexgen Chemicals, Nikunj Chemicals, Nithyasri Chemicals, Pacific Chemicals Company, Powder Pack Chem, Redox, Shanpar, Refractory Minerals Company, The Mosaic Company, and Triveni Chemicals.

The report provides a comprehensive analysis of the business aspects such as the global Magnesium Phosphate market size, recent technological advancements, and inventions. The research report includes: market introduction, major players, opportunities, restraints, classification of products and types, and overall analysis of the market. This research study aims to help take the right steps before starting a business, draw business conclusions, and shape the future of organizations. For ease of the reader, this global market research presentation establishes the overall forecast timeline, allowing a detailed market approximation on the likelihood of growth in the market.

The research on the Global Magnesium Phosphate Market 2021 provides a basic overview of the industry including definitions, classifications, applications, and industry chain structure. The global Magnesium Phosphate market share report is provided for the international markets as well as development trends, competitive landscape analysis, and key regions development status. Development policies and plans are discussed as well as manufacturing processes and cost structures are also analyzed. This report further shows the import / export consumption, supply and demand figures, costs, prices, revenues and gross margins.

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Sulfuric Acid Market to Secure a Notable Revenue Share over the Period 2021-2027 – Bulk Solids Handling https://imphos.org/sulfuric-acid-market-to-secure-a-notable-revenue-share-over-the-period-2021-2027-bulk-solids-handling/ https://imphos.org/sulfuric-acid-market-to-secure-a-notable-revenue-share-over-the-period-2021-2027-bulk-solids-handling/#respond Wed, 22 Sep 2021 12:02:47 +0000 https://imphos.org/sulfuric-acid-market-to-secure-a-notable-revenue-share-over-the-period-2021-2027-bulk-solids-handling/ The molecular formula of sulfuric acid is’ H2SO4. It is classified as a strong mineral acid with high corrosive capacities. Sulfuric acid is a viscous liquid soluble in water and varies in color from yellow to colorless, depending on its concentration. Sulfuric acid is used in the manufacture of commercially important chemicals such as hydrochloric […]]]>

The molecular formula of sulfuric acid is’ H2SO4. It is classified as a strong mineral acid with high corrosive capacities. Sulfuric acid is a viscous liquid soluble in water and varies in color from yellow to colorless, depending on its concentration. Sulfuric acid is used in the manufacture of commercially important chemicals such as hydrochloric acid, nitric acid, sulfate salts, synthetic detergents, dyes, pigments, explosives, and drugs.

Sulfuric acid is used in the production of phosphate fertilizers such as monoammonium phosphate, diammonium phosphate, dihydric calcium phosphate and others. According to the Food and Agriculture Organization (FAO), global demand for phosphate fertilizers in 2017 was 43.2 million tonnes. The FAO has estimated that this demand will increase to 45.8 million tonnes by 2020. Thus, the increasing demand for phosphate fertilizers is expected to drive the growth of the global sulfuric acid market.

Sulfuric acid market is expected to reach USD 8.11 billion by 2020, at a cagr rate of 1.87% during the forecast period

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The major market players operating in the Sulfuric Acid Market are PVS Chemical Solution and Phelps Dodge, CF Industries, The Mosaic, AkzoNobel NV, Agrium Inc., Rhodia, Langeloth International, Honeywell International, Bayer AG, DuPont de Nemours & Co., Potash Corp (PCS Phosphate), Chevron Corporation, Lucite International , Chemtrade Logistics, Southern States Chemical, Climax Molybdenum Co., Big River Zinc Sauget, Cytec Industries, Tampa Electric, Solvay SA, Evonik Industries, Chemtrade Refinery Services, BP Valero Energy and The Doe Run.

What market factors are explained in the report?

The sulfuric acid market is segmented on the basis of type, application, and region. A Full Explanation of Market Buildup methodology, the use of advancement, the conclusions of global market players have been given. The segmentation study identifies the major segments and explains the key factors that are supporting their growth in the global Sulfuric Acid market. The report then sheds light on the positioning of the product, customer perception of market competition, customer segmentation, consumer buying behavior, customer needs and target customers.

The report provides:

Market Snapshot

♦ Complete market analysis

Recent market developments

Market development in recent years

♦ Emerging segments and regional markets

♦ Segmentations up to the second and / or third level

♦ Historical, current and estimated market size in terms of value and volume

♦ Competitive analysis with an overview of the company, products, revenues and strategies

♦ Strategic recommendations that help companies increase their presence in the market

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In this study, the years considered to estimate the market size of the Sulfuric Acid market are as follows:

Year of history: 2013-2018
Year of reference: 2019
Estimated year: 2020
Forecast year: 2020 to 2027

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The secret of cellular energy revealed by a supercomputer https://imphos.org/the-secret-of-cellular-energy-revealed-by-a-supercomputer/ https://imphos.org/the-secret-of-cellular-energy-revealed-by-a-supercomputer/#respond Tue, 21 Sep 2021 15:55:03 +0000 https://imphos.org/the-secret-of-cellular-energy-revealed-by-a-supercomputer/ Supercomputer simulations have revealed for the first time how voltage-dependent anion channels in mitochondrial cells (VDACs) bind to the enzyme hexokinase-II (HKII). An artistic representation of the formation of a complex of the cytosolic enzyme hexokinase (light blue) on the surface of the outer membrane of mitochondria followed by the endogenous membrane protein VDAC (dark […]]]>

Supercomputer simulations have revealed for the first time how voltage-dependent anion channels in mitochondrial cells (VDACs) bind to the enzyme hexokinase-II (HKII). An artistic representation of the formation of a complex of the cytosolic enzyme hexokinase (light blue) on the surface of the outer membrane of mitochondria followed by the endogenous membrane protein VDAC (dark blue). ATP (red) is phosphorylated by HKII. This basic research helps researchers understand the molecular basis of diseases such as cancer. Credits: Haloi, N., Wen, PC. , Cheng, Q. et al.

As the saying goes, the tango costs two.

This is especially true for scientists who study the details of how cells work. Intracellular protein molecules interact with other proteins and, in a sense, proteins dance with their partners to respond to signals and regulate the activities of others.

The migration of a compound called adenosine triphosphate (ATP) from the mitochondria that train cells is important for giving cells life energy. And what’s important for this output to the energy-consuming parts of the cell is the interaction of a protein enzyme called hexokinase-II (HKII) with a voltage-gated anion channel protein (VDAC) in the outer mitochondrial membrane. is.

Supercomputer simulations revealed for the first time how VDACs bind to HKII. This task was supported by a mission assigned by the Extreme Science and Engineering Discovery Environment (XSEDE) to the Stampede2 system at the Texas Advanced Computing Center (TACC). XSEDE is funded by the National Science Foundation.

This basic research into how proteins interact with the cell’s driving force, the mitochondria, helps researchers understand the molecular basis of diseases such as cancer.

Emad Tajkhorshid, Chairman of the Biochemistry Donation Committee, J. Woodland Hastings, University of Illinois at Urbana-Champaign, said, “It was a million dollar question.

Tajkhorshid, Nature Communications Biology The study found that when the enzymes and proteins in the channels bind to each other, the conduction of the channels changes and the flow of ATP is partially blocked. Simulations on TACC’s Stampede2 system revealed this coupling.

Additionally, the Ranch system assigned to TACC’s XSEDE maintains persistent offsite file storage for research data.

“Without XSEDE, we couldn’t afford to study many of these complex biological projects and systems because we couldn’t afford to execute them. Usually long simulations are required and several of these simulations. I need a copy. It is scientifically convincing. It is impossible without XSEDE. We have to go back to studying smaller systems, ”says Tajkhorshid.

This study affects not only healthy cells, but also a better understanding of cancer cells.

Basically, cells need ATP to metabolize glucose. The “P” is used to convert glucose into glucose phosphate, providing a “handle” that the cell can use. Hexokinase-II causes conversion, binds in mitochondrial channels, swallows ATP and phosphorylates.

“We have shown how phosphorylation affects the binding process between two proteins, which has also been validated experimentally,” explains Tajkhorshid.

VDAC channels are important for the direct and efficient delivery of ATP to hexokinase. “It can act like a double-edged sword. For healthy cells, that’s good. For cancer cells, it also helps cells grow and proliferate, ”he said.

The Tajkhorshid team has developed the most detailed and sophisticated model of the complex formed by the binding of HKII and VDAC to date, combining all atoms with the highest resolution. Molecular dynamics simulation Use the coarser Brownian dynamics method. The size of the VDAC-HKII complex system was approximately 700,000 atoms including the membrane. It is about a fifth of the diameter of the COVID-19 virus.

Po-Chao Wen, postdoctoral researcher at the NIH Polymer Modeling and Bioinformatics Center at the University of Illinois at Urbana-Champaign, said:

The Stampede2 (left) and Ranch (right) systems receive resources from the Extreme Science and Engineering Discovery Environment (XSEDE) funded by the National Science Foundation (NSF). Credit: TACC

Wen explained that their simulation design began with the hypothesis that the VDAC protein in the outer membrane could fully interact with HKII, which is localized in different parts of the cell called the cytosol. They hypothesized that HKII should first bind to the membrane and drift onto the membrane until it reaches the VDAC protein.

The VDAC on the membrane is already well modeled, and based on this knowledge, the researchers decomposed the modeling of the HKII-VDAC complex into three parts, initially focusing on HKII.

To study how HKII binds to the outer membrane of mitochondria, they use the molecular dynamics of all atoms and tools developed by a center called the Highly Mobile Membrane Model (HMMM) which deals with membrane interactions. I used it.

Next, using Brownian dynamics, we investigated how HKII drifts on the membrane to adapt to VDAC, and numerous encounter / collision events between the seated VDAC and the drift HKII on the plane membrane. created.

“Then we used the molecular dynamics of the whole atom to get a more sophisticated model of the interaction and a particular size, and looked for that particular protein-protein interaction,” Wen added. .. This made it possible to find the more stable complex of the two proteins formed.

“The millisecond-to-second long timescale of all-atom simulations seemed almost impossible when we started this process,” said Nandan, co-author of the study and a doctoral student at the center. “Halloy said.

Many other computer tools have been developed by the group, in particular NAMD, which is commonly used in molecular dynamics.

“These are very expensive calculations and cost millions of dollars to set up independently, and you have to run them on a parallel supercomputer using NAMD code. Otherwise, you will need it. We couldn’t reach the timescale, ”explains Tajkhorshid.

“I am very pleased with TACC and TACC’s support for most projects and software development, software tuning and acceleration, and this work. TACC is great for supporting us, ”Tajkhorshid said. said sir.

TACC scientists are working with the NIH Polymer Modeling and Bioinformatics Center to continuously optimize the NAMD software currently used by thousands of researchers.

The next stage of the study will include more ambitious systems such as the merger of the two. cell It is important to understand how neurons in the brain signal to each other. And how new viruses, such as the coronavirus, fuse with host cells.

Tajkhorshid’s group has received a leadership resource allocation for the NSF-funded flagship Frontera supercomputer at TACC to investigate some of these ambitious projects.

“Our research focuses on molecular systems and processes, how molecules bind together, how they work, and how people change their structure to achieve a particular function,” Tajkhorshid said. I like to think of it as a computer microscope that can see. ”Measure indirectly and experimentally. Supercomputers are essential in providing this level of detail and can be used to understand the molecular basis of disease, drug discovery, etc. “


Researchers elucidate the mechanism of protein transport in mitochondria


For more information:
Nandan Haloi et al, Structural basis for the formation of complexes between the mitochondrial anion channel VDAC1 and hexokinase-II, Communication biology (2021). DOI: 10.1038 / s42003-021-02205-y

Provided by
Texas Advanced Computing Center

Quote: Secrets of Cellular Energy Revealed on Supercomputers (September 21, 2021) from https: //phys.org/news/2021-09-cell-energy-secrets-revealed-supercomputers.html 2021 Obtained September 21

This document is subject to copyright. No part may be reproduced without written permission, except for fair dealing for the purposes of personal investigation or research. The content is provided for informational purposes only.


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Specialty Fertilizers Market by Covid-19 Impact, Global Business Scenario, Overview with Product Scope, Risk of Opportunities, Market Driving Force to 2027 https://imphos.org/specialty-fertilizers-market-by-covid-19-impact-global-business-scenario-overview-with-product-scope-risk-of-opportunities-market-driving-force-to-2027/ https://imphos.org/specialty-fertilizers-market-by-covid-19-impact-global-business-scenario-overview-with-product-scope-risk-of-opportunities-market-driving-force-to-2027/#respond Tue, 21 Sep 2021 09:31:45 +0000 https://imphos.org/specialty-fertilizers-market-by-covid-19-impact-global-business-scenario-overview-with-product-scope-risk-of-opportunities-market-driving-force-to-2027/ Specialty Fertilizers market research report gives CAGR value, industry chains, upstream, geography, end user, application, competition analysis, SWOT analysis, sales, revenue, price, gross margin, market share, import-export, trends and forecasts. The report also provides an overview of barriers to entry and exit of the global industry. The specialty fertilizers market is expected to be worth […]]]>

Specialty Fertilizers market research report gives CAGR value, industry chains, upstream, geography, end user, application, competition analysis, SWOT analysis, sales, revenue, price, gross margin, market share, import-export, trends and forecasts. The report also provides an overview of barriers to entry and exit of the global industry.

The specialty fertilizers market is expected to be worth $ 37.6 billion in 2021 and is expected to grow at a CAGR of + 6% from 2021, reaching a value of $ 51.3 billion by 2027.

The study report offers a comprehensive analysis of the Specialty Fertilizers market size across the globe as a regional and country level market size analysis, CAGR estimate of the market growth over the period forecasting, revenue, key drivers, competitive environment and payor sales analysis.

Along with this, the report explains the main challenges and risks to be faced during the forecast period. The specialty fertilizer market is segmented by type and by application. Players, stakeholders, and other participants of the Global Specialty Fertilizers Market will be able to gain the upper hand by utilizing the report as a powerful resource.

Key players

  • Yara International
  • NPS
  • Haifa chemicals
  • Sinochem Group
  • Agrium
  • The Mosaic Company
  • LCI
  • MAHAFEED
  • Evergrow
  • Shidanli
  • NUTECH
  • Novagro
  • AG Specialties
  • Kugler
  • Mars Vista Resources
  • Kingenta
  • Aglukon

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Here are the main points covered in this report:

  • The number of procedures performed and the average cost.
  • Replacement rate and pricing for capital goods.
  • Commercial dynamics in relation to the market in question – Trends, drivers, constraints and opportunities.
  • New product launches, market and technological trends and innovation.

The report further elaborates with market SWOT analysis, investment viability analysis and ROI analysis and establishes a strategic perspective for the pandemic.

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Market segmentation

By type

  • Monoammonium phosphate
  • Monopotassium phosphate
  • Potassium nitrate
  • Potassium chloride
  • Potassium sulphate
  • Urea
  • UAN
  • Others

By application

  • Fruits and vegetables
  • Cereals and oilseeds
  • Rest

Regional analysis:

  • North America (United States, Canada and Mexico)
  • Europe (Germany, France, United Kingdom, Russia and Italy)
  • Asia Pacific (China, Japan, Korea, India and Southeast Asia)
  • South America (Brazil, Argentina, Colombia, etc.)
  • The Middle East and Africa (Saudi Arabia, United Arab Emirates, Egypt, Nigeria and South Africa)

Study and analyze the impact of the Coronavirus COVID-19 On the Left-Handed Specialty Fertilizer Industry, the report provides in-depth analysis and professional advice on how to cope with the post COIVD-19 period

Detailed TOC of Specialty fertilizers Market Research Report-
1. Introduction.
2. Analysis of the market methodology.
3. Analysis of market strategies.
4. Market demand, supply, trend analysis.
5. Market overview with key players
6. Analysis of Porte’s five force model.
7. Market segmentation by region, type and application.
8. Analysis of the advantages and limitations of the market.
9. SWOT analysis of projects.
10. Conclusion.
11. Annex.

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TACC’s HPC Stampede2 simulations reveal how cells regulate https://imphos.org/taccs-hpc-stampede2-simulations-reveal-how-cells-regulate/ https://imphos.org/taccs-hpc-stampede2-simulations-reveal-how-cells-regulate/#respond Mon, 20 Sep 2021 21:41:29 +0000 https://imphos.org/taccs-hpc-stampede2-simulations-reveal-how-cells-regulate/ (Left to right) Po-Chao Wen, Nandan Haloi and Emad Tajkhorshid from the University of Illinois at Urbana-Champaign Supercomputer simulations performed on the Texas Advanced Computing Center (TACC) Stampede2 system have helped scientists studying cell function understand how protein molecules dance with a partner to respond to signals and regulate the activities of others. . The […]]]>

(Left to right) Po-Chao Wen, Nandan Haloi and Emad Tajkhorshid from the University of Illinois at Urbana-Champaign

Supercomputer simulations performed on the Texas Advanced Computing Center (TACC) Stampede2 system have helped scientists studying cell function understand how protein molecules dance with a partner to respond to signals and regulate the activities of others. .

The migration of a compound called adenosine triphosphate (ATP) out of the cell’s powerhouse, the mitochondria, is crucial in providing cells with vital energy. And the interaction between a protein enzyme called hexokinase-II (HKII) and voltage-gated anion channel (VDAC) proteins located on the outer membrane of mitochondria is essential for this flow to energy-consuming parts of the cell.

HPC simulations revealed for the first time how VDAC binds to HKII. The work was supported by grants awarded by the Extreme Science and Engineering Discovery Environment (XSEDE) on Stampede2. XSEDE is funded by the National Science Foundation.

This basic research into how proteins interact from the cell’s powerhouse, the mitochondria, will help researchers understand the molecular basis of diseases such as cancer.

“We had strong evidence that they bond, but we didn’t know how they bond to each other,” said Emad Tajkhorshid, J. Woodland Hastings Chair in Biochemistry at the University of Illinois. in Urbana-Champaign. “That was the million dollar question.”

Tajkhorshid is co-author of a study published in Nature Communications Biology, June 2021. The study found that when the enzyme and channel proteins bind to each other, the conduction of the channel changes and partially blocks the flow. of ATP. Simulations on TACC’s Stampede2 system have revealed this connection.

In addition, the Ranch system allocated by XSEDE to TACC holds permanent offsite file storage for study data.

HPC simulations reveal how the cell’s mitochondrial voltage-dependent anion channel (VDAC) binds to the enzyme hexokinase-II (HKII). Artistic representation of the membrane binding of the cytosolic enzyme Hexokinase (light blue), followed by its complex formation with the integral membrane protein VDAC (dark blue), on the surface of the outer membrane of the mitochondria. ATP (red) is phosphorylated by HKII. Credit: Haloi, N., Wen, PC., Cheng, Q. et al.

“If it weren’t for XSEDE, we wouldn’t be studying many of these complex biological projects and systems because you just can’t afford to run the simulation. They usually require long simulations, and we need multiple copies of these simulations to be scientifically convincing. Without XSEDE, it is impossible. We will have to go back to studying smaller systems, ”Tajkhorshid said.

This work has implications for a better understanding not only of healthy cells, but also of cancer cells.

Basically, a cell needs ATP to metabolize glucose. It uses the “P” to convert glucose into glucose phosphate, giving it a “handle” that the cell can use. Hexokinase-II enables conversion by binding to the mitochondrial channel to engulf ATP and phosphorylate it.

“We have shown how phosphorylation affects this binding process between the two proteins. This has also been verified experimentally, ”Tajkhorshid said.

The VDAC channel is essential for efficient delivery of ATP directly to hexokinase. “It can work like a double-edged sword. For a healthy cell this is good. For a cancer cell, it also helps the cell to grow and proliferate, ”he said.

The Tajkhorshid team has developed the most detailed and sophisticated model to date of the complex formed by the binding of HKII and VDAC, combining molecular dynamics simulations of all atoms at the highest resolution with techniques of coarser Brownian dynamics. The size of the VDAC-HKII complex system was approximately 700,000 atoms including the membrane. It is about a fifth of the diameter of the COVID-19 virus.

“What emerges from our approach is that we actually took into account the cell background of this interaction,” said Po-Chao Wen, postdoctoral research associate at the NIH Center for Macromolecular Modeling and Bioinformatics, University of Illinois. at Urbana-Champaign.

Wen explained that their simulation design began with the hypothesis that the VDAC protein in the outer membrane could interact with HKII, which is located in a different part of the cell called the cytosol. They hypothesized that HKII should first bind to the membrane, drifting over it until it reached a VDAC protein.

The membrane-seated VDAC has already been well modeled, and the researchers used this knowledge to decompose the modeling of the HKII-VDAC complex into three parts, initially focused on HKII.

To study how HKII binds to the mitochondrial outer membrane, they used the molecular dynamics of all atoms and a tool developed by their center called the Highly Mobile Membrane Model (HMMM), which deals with membrane interaction.

Stampede2 (left) and Ranch (right). Credit: TACC

They then used Brownian dynamics to study how HKII drifts across the membrane to meet VDAC, creating numerous encounter / collision events between a seated VDAC and an HKII adrift on a flat membrane.

“Then we used the molecular dynamics of all the atoms to get a more refined model and specific size of the interaction to look for that particular protein-protein interaction,” Wen added. This helped them find the more stable complex of the two proteins formed.

“It seemed almost impossible when we started this process, due to the long timescales of a few milliseconds to seconds of all-atom simulations,” said study co-author Nandan Haloi, also a doctoral student at the center.

Many other computer tools have been developed by the group, including the NAMD commonly used for molecular dynamics.

“These are really expensive calculations, which would require millions of dollars to set up independently. And you have to run on parallel supercomputers using our NAMD code, otherwise we might not be able to meet the times we needed, ”Tajkhorshid said.

“We are extremely satisfied with TACC and their support not only for this work, but also for most of our projects and also for the development of our software, optimizing the software and making it faster. TACC has been great in supporting us, ”said Tajkhorshid.

TACC scientists are working with the NIH Center for Macromolecular Modeling and Bioinformatics to continuously optimize the NAMD software, currently used by thousands of researchers.

The next steps in the research include more ambitious systems such as the fusion of two cells, important for understanding how neurons in the brain fire signals; and how a virus such as the novel coronavirus fuses with the host cell.

Tajkhorshid’s group has received a leadership resource allocation on the NSF-funded flagship Frontera supercomputer at TACC to investigate some of these ambitious projects.

Tajkhorshid said, “We like to think of our work as a computer microscope that examines molecular systems and processes, how molecules come together, how they move and how they change their structure to perform a particular function that people have. summer. indirect measurement experimentally. Supercomputers are essential in providing this level of detail, which we can use to understand the molecular basis of diseases, drug discovery, etc.

The study, “Structural basis of the complex formation between the mitochondrial anion channel VDAC1 and hexokinase-II”, was published in June 2021 in the journal Nature Communications Biology. The authors of the study are Nandan Haloi, Po-Chao Wen, and Emad Tajkhorshid of the University of Illinois at Urbana-Champaign; Qunli Cheng, Meiying Yang, Gayathri Natarajan, Amadou KS Camara, and Wai-Meng Kwok of the Medical College of Wisconsin.

This research was funded by grants R01-HL131673 and P41-GM104601. from the National Institutes of Health. The simulations for this study were performed using allocations to the National Science Foundation Supercomputing Centers (grant number XSEDE MCA06N060) and the Blue Waters supercomputer from the National Center for Supercomputing Applications at the University of Illinois. in Urbana-Champaign.

source: Jorge Salazar, TACC


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Phosphate Conversion Coatings for Oil & Gas Market 2021 Future Growth Explored in Latest Research Report by 2028 – Stillwater Current https://imphos.org/phosphate-conversion-coatings-for-oil-gas-market-2021-future-growth-explored-in-latest-research-report-by-2028-stillwater-current/ https://imphos.org/phosphate-conversion-coatings-for-oil-gas-market-2021-future-growth-explored-in-latest-research-report-by-2028-stillwater-current/#respond Mon, 20 Sep 2021 10:05:46 +0000 https://imphos.org/phosphate-conversion-coatings-for-oil-gas-market-2021-future-growth-explored-in-latest-research-report-by-2028-stillwater-current/ Global Phosphate conversion coatings for the oil and gas market To provide comprehensive data on the current market scenario and provide solid information regarding the potential market size, volume and dynamics. Phosphate conversion coatings for oil and gas market size is expected to grow at a compound annual growth rate of 4.73% for the forecast […]]]>

Global Phosphate conversion coatings for the oil and gas market To provide comprehensive data on the current market scenario and provide solid information regarding the potential market size, volume and dynamics. Phosphate conversion coatings for oil and gas market size is expected to grow at a compound annual growth rate of 4.73% for the forecast period 2021 to 2028. The analysis study offers a comprehensive analysis important aspects of the global oil and gas phosphate conversion coatings market. , with competition, segmentation, geographical progress, production of analyzes and value structure. We have provided the CAGR, value, volume, sales, production, revenue, and various estimates for all over the world as regional markets.

The business insights gained from the Large-Scale Phosphate Conversion Coatings for Oil and Gas Business Analysis Report facilitate a great understanding of the business landscape, the issues that will interrupt in the future, and ways to perfectly position ourselves. . These data and commercial information allow to increase or to minimize the assembly of products according to the conditions of the demand. This activity report could be a great guide to Associate in Nursing’s unfair ideas, increased decision making, and higher business methods. All the information and statistics provided in the First Class Phosphate Conversion Coatings for Oil and Gas Business Report are recorded by the latest and proven tools and techniques, such as SWOT analysis and 5 force analysis by Porter.

Request for Sample Copy of this Premium Analysis Phosphate Conversion Coatings for Oil & Gas Market:https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-phosphate-conversion-coatings-for-oil-and-gas-market

Major Key Players in the Oil & Gas Phosphate Conversion Coatings Market:

Henkel Adhesives Technologies India Private Limited, Crest Chemicals, PPG Industries, Axalta Coating Systems, LLC, BASF SE, Freiborne Industries, Nihon Parkerizing India Pvt. Ltd., Hubbard-Hall, Keystone Corporation, The Sherwin Williams Company, Westchem Technologies Inc., Kansai Paint Co., Ltd., Pioneer Metal Finishing and NuGenTec

The Oil & Gas Phosphate Conversion Coatings market is segmented as follows:

Global Oil & Gas Phosphate Conversion Coatings Market, By Product Type (Zinc Phosphate, Manganese Phosphate, Iron Phosphate), Substrate (Steel, Cast Iron, Others), Country (United States, Canada, Mexico, Brazil, Argentina, Rest of South America, Germany, France, Italy, United Kingdom, Belgium, Spain, Russia, Turkey, Netherlands, Switzerland, Rest of Europe, Japan, China, India, South Korea, Australia, Singapore, Malaysia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific, United Arab Emirates, Saudi Arabia, Egypt, South Africa, Israel, Rest of Middle East and Africa) Trends and Forecasts industry until 2028

For Inquiry or Customization of Phosphate Conversion Coatings For Oil & Gas Report Click Here: https://www.databridgemarketresearch.com/inquire-before-buying/?dbmr=global-phosphate-conversion-coatings-for-oil-and-gas-market

Regional Analysis For Oil and Gas Phosphate Conversion Coatings Market:

In addition to the segmental breakdown, the report is extremely structured into a study by region. The regional analysis comprehensively performed by the researchers highlights key regions and their dominant countries accounting for a substantial revenue share within the Oil & Gas Phosphate Conversion Coatings market. The study helps to understand how the market can evolve in the different regions while also mentioning the rising regions which are growing with a major CAGR.

The following are the regions covered during this report.

North America [U.S., Canada, Mexico]

Europe [Germany, UK, France, Italy, remainder of Europe]

Asia Pacific [China, India, Japan, Asian country, Southeast Asia, Australia, remainder of Asia Pacific]

South America [Brazil, Argentina, remainder of Latin America]

Middle East and Africa [GCC, geographic region, Republic of South Africa, remainder of geographical area and Africa]

The table of contents is available here @ https://www.databridgemarketresearch.com/toc/?dbmr=global-phosphate-conversion-coatings-for-oil-and-gas-market

Highlights of the report:

>> A detailed survey of the company

>> Changing business trends around the world for the Oil and Gas Phosphate Conversion Coatings market

>> Coincident analysis of several parameters is important to denote the prevalence of Phosphate Conversion Coatings for Oil & Gas market.

>> Detailed marketing research at a completely different level like sorting, application, end user, regions / countries

>> Historical and forecast market size in terms of revenue (USD million)

>> It helps to understand key product segments and their future

>> Analysis of the competitive landscape and the positioning of players on the market

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    Sorrento Announces Independent Real-World Study Reporting Superior Sensitivity Results in Detection of COVID-19 Virus Infections in the General Population of All Comers by COVISTIX Compared to a World Leading Rapid Antigen Test https://imphos.org/sorrento-announces-independent-real-world-study-reporting-superior-sensitivity-results-in-detection-of-covid-19-virus-infections-in-the-general-population-of-all-comers-by-covistix-compared-to-a-world/ https://imphos.org/sorrento-announces-independent-real-world-study-reporting-superior-sensitivity-results-in-detection-of-covid-19-virus-infections-in-the-general-population-of-all-comers-by-covistix-compared-to-a-world/#respond Sun, 19 Sep 2021 18:58:00 +0000 https://imphos.org/sorrento-announces-independent-real-world-study-reporting-superior-sensitivity-results-in-detection-of-covid-19-virus-infections-in-the-general-population-of-all-comers-by-covistix-compared-to-a-world/ As a general screening for all arrivals (that is to say Symptomatic and asymptomatic populations of COVID-19), COVISTIX (n = 783) has a sensitivity of 81% versus 62% (n = 2202) of sensitivity by the world-leading Panbio rapid antigen test. SAN DIEGO, September 19, 2021 (GLOBE NEWSWIRE) – Sorrento Therapeutics, Inc. (Nasdaq: SRNE, “Sorrento”), a […]]]>
    • As a general screening for all arrivals (that is to say Symptomatic and asymptomatic populations of COVID-19), COVISTIX (n = 783) has a sensitivity of 81% versus 62% (n = 2202) of sensitivity by the world-leading Panbio rapid antigen test.

    SAN DIEGO, September 19, 2021 (GLOBE NEWSWIRE) – Sorrento Therapeutics, Inc. (Nasdaq: SRNE, “Sorrento”), a clinical and commercial-stage biopharmaceutical company developing new therapies to treat cancer and pain (non opioids), autoimmune disease and COVID-19, today announced the impressive results of an independent study conducted under real field conditions by INMEGEN (National Institute of Genomic Medicine, Mexico).

    Detailed results are available at: https://www.medrxiv.org/content/10.1101/2021.09.10.21263410v1

    Analytical performance of the COVISTIX ™ and Panbio ™ rapid antigenic tests for the detection of SARS-CoV-2 in an unselected population (all came) ”

    Highlights include:

    • For the population tested with COVISTIX ™ (n = 783), the sensitivity and specificity were 81% (95% CI 76.0-85.0) and 96.0% (95% CI 94.0-98.0), respectively. In contrast, the sensitivity of the Panbio comparator test (n = 2202) was measured at 62% (95% CI: 58.0-64.0%) and the specificity at 99.0% (95% CI: 0.99-1 , 00).

    This finding is important because higher COVISTIX sensitivity means fewer false negatives, which is essential for managing the spread of COVID virus infection and preventing COVID disease, especially cases related to highly transmissible variants of concern such as than the Delta variant. Additionally, this superior sensitivity result is quite impressive in an actual population of all arrivals (compared to symptomatic patients only) using an initial shallow nasal sampling protocol followed by optional nasopharyngeal sampling, if desired.

    About Sorrento Therapeutics, Inc.

    Sorrento is a clinical and commercial biopharmaceutical company developing new therapies to treat cancer, pain (non-opioid treatments), autoimmune diseases and COVID-19. Sorrento’s multimodal and multidimensional approach to fighting cancer is made possible by its extensive immuno-oncology platforms, including key assets such as fully human antibodies (“G-MAB ™ library”), immune therapies -cellular (“DAR-T ™”), antibody-drug conjugates (“ADC”) and oncolytic virus (“Seprehvec ™”). Sorrento is also developing antiviral therapies and potential coronavirus vaccines, including Abivertinib, COVIGUARD ™, COVI-AMG ™, COVISHIELD ™, COVI-MSC ™ and COVIDROPS ™; and diagnostic test solutions, including COVITRACK ™, COVISTIX ™ and COVITRACE ™.

    Sorrento’s commitment to life-enhancing therapies is also demonstrated by our efforts to advance a first-class non-opioid pain management small molecule (TRPV1 agonist), resiniferatoxin (“RTX”), and SP-102 (10 mg, dexamethasone sodium phosphate viscous gel) (SEMDEXA ™), a new viscous gel formulation of a corticosteroid widely used for epidural injections to treat lumbosacral radicular pain, or sciatica, and to market ZTlido® (lidocaine topical system) 1.8% for the treatment of postherpetic neuralgia. RTX has completed a Phase IB trial for intractable pain associated with cancer and a Phase 1B trial in patients with osteoarthritis. SEMDEXA is in a pivotal phase 3 trial for the treatment of lumbosacral radicular pain, or sciatica. ZTlido® was approved by the FDA on February 28, 2018.

    For more information, visit www.sorrentotherapeutics.com.

    Forward-looking statements

    This press release and all statements made for and during any presentation or meeting contain forward-looking statements relating to Sorrento Therapeutics, Inc., under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995 and subject to risks and uncertainties. which could cause actual results to differ materially from those projected. Forward-looking statements include statements regarding expectations regarding Sorrento’s technologies and product candidates, including, but not limited to, Sorrento’s COVISTIX diagnostic test; the specificity and sensitivity of COVISTIX; the possibility that COVISTIX will offer fewer false negative results, including in cases involving a variant of SARS-CoV-2 of concern; and Sorrento’s potential position in the antiviral industry. Risks and uncertainties that could cause our actual results to differ materially and adversely from those expressed in our forward-looking statements, include, without limitation: risks relating to Sorrento’s technologies and prospects, including, but not limited to: ” limit the risks associated with conducting clinical studies and requesting regulatory approval for COVISTIX; the clinical and commercial success of COVISTIX; clinical development risks, including risks related to the progress, timing, costs and results of clinical trials and product development programs; risk of difficulties or delays in obtaining regulatory approvals; the risks that the results of a clinical study will not meet all or part of the parameters of a clinical study and that the data generated from these studies may not support a regulatory submission or approval; the risks that the results of previous trials, studies and trials will not be reproduced in future studies and trials; risks associated with the manufacture and supply of pharmaceutical products; risks associated with using the expertise of its employees, subsidiaries, affiliates and partners to assist Sorrento in the execution of its therapeutic drug candidate strategies; risks associated with the global impact of COVID-19; and other risks which are described in Sorrento’s most recent periodic reports filed with the Securities and Exchange Commission, including Sorrento’s annual report on Form 10-K for the fiscal year ended December 31, 2020, and subsequent quarterly reports on Form 10-Q filed with the Securities and Exchange Commission, including the risk factors set out in those documents. Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release, and we assume no obligation to update any forward-looking statements in this press release, unless the law requires it.

    Media contact and investor relations
    Alexis Nahama, DVM (SVP Business Development)
    E-mail: mediarelations@sorrentotherapeutics.com

    Sorrento® and the Sorrento logo are registered trademarks of Sorrento Therapeutics, Inc.

    G-MAB ™, DAR-T ™, SOFUSA ™, MuVAXX ™, COVIGUARD ™, COVI-AMG ™, COVISHIELD ™, COVIDROPS ™, COVI-MSC ™, COVITRACK ™, COVITRACE ™ and COVISTIX ™ are trademarks of Sorrento Therapeutics, Inc.

    SEMDEXA ™ is a trademark of Semnur Pharmaceuticals, Inc.

    ZTlido® is a registered trademark owned by Scilex Pharmaceuticals Inc.

    All other trademarks are the property of their respective owners.

    © 2021 Sorrento Therapeutics, Inc. All rights reserved.


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