BOC Sciences announced its participation in TIDES USA 2021 in September
New York, United States – August 6, 2021 – Recently, BOC Sciences announced that it has registered to attend the TIDES USA 2021 conference to meet more professionals in the pseudo-uridine industry and seek business cooperation.
TIDES USA (Oligonucleotide & Peptide Therapeutics Conference) is the world’s largest gathering of people interested in accelerating the development and commercialization of oligonucleotides, peptides, mRNAs and genome-editing products, from initial discovery to subsequent steps. Each year, TIDES ‘scientific agenda includes over 150 top industry scientists and features the latest scientific and industry updates across the field, from discovery, preclinical and clinical development to CMC. , manufacturing and marketing of therapeutic drugs and vaccines for oligos, peptides, mRNA and genome editing products.
BOC Sciences has become the world’s largest supplier of PseudoUridine with the largest production capacity. The current annual production of PseudoUridine exceeds 500 kilograms. It should be noted that the high purity pseudo-uridine supplied by BOC Sciences was used as the raw material for the SARS-CoV-2 mRNA vaccine, which solves the problem of the lack of raw materials during the initial development of the vaccine. .
In addition to PseudoUridine, BOC Sciences also provides a multitude of Pseudo-uridine derivatives, which can be divided into four categories: Modified PseudoUridine, PseudoUridine phosphate, PseudoUridine phosphoramidite, Isotope-labeled PseudoUridine.
Altered nucleotides are found in almost all types of naturally occurring RNA. There are about 100 different basic modifications known, and they can serve several functions. PseudoUridine (CAS 1445-07-4), called the fifth RNA residue, is the most common modification in RNA. Pseudo-uridine is commonly found in ribosomal RNA (rRNA) and is ubiquitous in transfer RNA (tRNA), small nuclear RNA (snRNA), and other non-coding RNAs (ncRNA). Recently, the importance of pseudo-uridine in the epigenetic regulation of mRNA function has become increasingly evident.
PseudoUridine phosphate is generally produced by phosphorylation occurring in the hydroxyl group at the 5 ‘position of the PseudoUridine ribose. PseudoUridine phosphate is a C nucleotide, in which the uracil part binds to the sugar through its carbon atom instead of a nitrogen atom to form a CC glycosidic bond. PseudoUridine phosphate can be divided into PseudoUridine 5′-monophosphate (ΨMP), PseudoUridine 5′-diphosphate (ΨDP) and PseudoUridine 5′-triphosphate (ΨTP) depending on the number of connected phosphates.
Phosphoramidites are used as building blocks in the chemical synthesis of oligonucleotides. Pseudo-uridine phosphoramidite can help introduce pseudo-uridine into RNA oligonucleotides. Pseudo-uridine phosphoramidite allows efficient and reliable synthesis of RNA containing single or multiple pseudo-uridine modifications. Pseudo-Uridine-modified mRNA has shown promising therapeutic potential in gene replacement and vaccination.
Pseudo-Uridine labeled with an isotope
Pseudo-uridine can be labeled with a stable 15N isotope at helix 69 of 23S rRNA from E. coli, which can help study the kinetics and interaction of this RNA fragment with ribosomes or separating ligands. These labeled nucleosides are important for exploring the biological effects of pseudo-Uridine and 3-methylPseudoUridine (CAS 81691-06-7).
BOC Sciences’ booth number at TIDES USA is # 874. And the company recently said it hopes to share more information about its production of pseudoadenosin with other exhibit attendees and seek more business cooperation opportunities.
For more information on BOC Sciences’ participation in this event, please visit the website: https://informaconnect.com/tides/sponsors/boc-sciences.
About BOC Sciences
BOC Sciences has professional experts who focus on research in many fields such as pharmacy, chemistry and life sciences, providing high quality products and services to scientists and researchers in academia and industry worldwide. . This company has become the world’s leading supplier of PseudoUridine with the largest production capacity.